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The Fourth International Workshop on Bio-Design Automation (IWBDA) at DAC will bring together researchers from the synthetic biology, systems biology, and design automation communities. The focus is on concepts, methodologies and software tools for the computational analysis of biological systems and the synthesis of biological systems.

Still in its early stages, the field of synthetic biology has been driven by experimental expertise; much of its success can be attributed to the skill of the researchers in specific domains of biology. There has been a concerted effort to assemble repositories of standardized components. However, creating and integrating synthetic components remains an ad hoc process. The field has now reached a stage where it calls for computer-aided design tools. The electronic design automation (EDA) community has unique expertise to contribute to this endeavor. This workshop offers a forum for cross-disciplinary discussion, with the aim of seeding collaboration between the research communities.

Topics of interest include:


Dates and Venue

Dates: **NEW DATE** Sunday-Monday, June 3-4

Venue: Moscone Center, San Francisco, CA

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The workshop is part of the 49th ACM/EDAC/IEEE Design Automation Conference (DAC), the premier conference in the field of electronic design automation with over 10,000 attendees. This year DAC will be held June 3-7, 2012 at the Moscone Center, San Francisco, CA.



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Abstract Submission

Abstracts should be two pages long, following the ACM SIG Proceedings templates at http://www.acm.org/sigs/publications/proceedings-templates. Indicate whether you would like your abstract considered for a poster presentation, an oral presentation, or both. Include the full names, affiliations and contact information of all authors.

Abstracts will be reviewed by the Program Committee. Those that are selected for oral and poster presentations will distributed to workshop participants and posted on the workshop website.

Abstracts should be submitted by April 2nd at: http://www.easychair.org/conferences/?conf=iwbda2012

Registration, Travel, and Hotel Information

Registration will be through the DAC website.

Registration for DAC 2012 will be available at: DAC Registration.

Please note that the registration deadline for the dinner is May 29th. As of May 21st, 35 of the 60 available dinner seats are full.

Registration rates can be found here.

Also, see travel and hotel information on the DAC website.

Student Support

If you are a student planning on attending the workshop this year, support funds may be available. Please send the following to finances@biodesignautomation.org by April 2nd April 9th, but we will accept applications as long as funds are available:

Requests for support will be evaluated according to the following criteria (in order of importance):

Call for Abstracts

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Key Dates

Call for participation published: February 3rd, 2012

Abstract submission deadline: April 2nd, 2012 extended to April 9th, 2012

Abstract acceptance notification: May, 11th

Workshop: **NEW DATE** June 3-4, 2012

Journal Publications

Looking to publish your research in the ACS Synthetic Biology IWBDA 2012 Special Issue?

Ensure your research gets the attention it deserves. ACS Synthetic Biology offers rapid publication of your research findings to scientists around the world. It also has the highest editorial standards and NO author submission, page, color, or cover art charges.

Please consider the following when submitting your manuscript:

Organizing Committee

Executive Committee:

Steering Committee:

Program Committee:


Invited Speakers:


Sunday – June 3rd

Location: Kuleto’s Italian Restaurant, 221 Powell Street, San Francisco, CA 94102

Phone: 415.397.7720

IWBDA Group Dinner: We're planning a dinner for IWBDA attendees Sunday night June 3rd. The dinner will take place at an Italian Restaurant near the convention center. We have a limited number of seats for dinner. We are emailing invitations based on the DAC registration list. To guarantee a seat at the dinner, please register ASAP. Please let us know (email: finances@biodesignautomation.org) if you register for other DAC events as we are giving priority to IWBDA only attendees. As of May 21st, 35 of the 60 available dinner seats are full.

Monday – June 4th


Abstracts & Proceedings


Title: Self-assembly of DNA into nanoscale three-dimensional shapes

Abstract: I will present a general method for solving a key challenge for nanotechnology: programmable self-assembly of complex, three-dimensional nanostructures. Previously, scaffolded DNA origami had been used to build arbitrary flat shapes 100 nm in diameter and almost twice the mass of a ribosome. We have succeeded in building custom three-dimensional structures that can be conceived as stacks of nearly flat layers of DNA. Successful extension from two-dimensions to three-dimensions in this way depended critically on calibration of folding conditions. We also have explored how targeted insertions and deletions of base pairs can cause our DNA bundles to develop twist of either handedness or to curve. The degree of curvature could be quantitatively controlled, and a radius of curvature as tight as 6 nanometers was achieved. This general capability for building complex, three-dimensional nanostructures will pave the way for the manufacture of sophisticated devices bearing features on the nanometer scale.

Title: Molecular computing: From games to practical applications

Abstract: This talk will focus on two molecular system capable of information processing: (i) Deoxyribozyme-based logic gates and various deoxyribozyme-based molecular automata playing games against human opponents; and (ii) Strand-displacement cascades and their ability to assess presence and absence of surface markers on cells.

Title: From Coding the Genome to Algorithms Decoding Life

Abstract: The decade of genomic revolution following the human genome's sequencing has produced significant medical advances, and yet again, revealed how complicated human biology is, and how much more remains to be understood. Biology is an extraordinary complicated puzzle; we may know some of its pieces but have no clue how they are assembled to orchestrate the symphony of life, which renders the comprehension and analysis of living systems a major challenge. Recent efforts to create executable models of complex biological phenomena - an approach we call Executable Biology - entail great promise for new scientific discoveries, shading new light on the puzzle of life. At the same time, this new wave of the future forces computer science to stretch far and beyond, and in ways never considered before, in order to deal with the enormous complexity observed in biology. This talk will focus on our recent success stories in using formal methods to model cell fate decisions during development and cancer, and on-going efforts to develop dedicated tools for biologists to model cellular processes in a visual-friendly way.

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